Diuretic effects of Bay g 2821 in patients with advanced renal failure

Summary

Clearance studies were carried out in 18 non-oedematous patients with advanced renal failure (glomerular filtration rate < 12 mljmiri) to assess the diuretic effects of Bay g 2821 given in different oral doses (120 mg to 360 mg). The results showed a significant increase in urinary volume and in clearances of sodium, calcium, magnesium, chloride, inorganic phosphorus and ⁵¹ CrEDTA. There were no significant changes, however, in clearance of PAH, urea and uric acid. The diuretic response started in the first hour after drug intake, reached a maximum after 3 to 5 hours, and declined slowly in the following 3 to 4 hours. Inpatients with a glomerular filtration rate < 3 ml/min the drug lost its effect. In rates between 5 to 10 ml/min the efficacy of Bay g 2821 was comparable to that of furosemide and ethacrynic acid. No side-effects were reported.

Key Words::

• Bay g 2821
• diuretics
• kidney failure
• acute