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Summary
Forty-one patients seen in general practice with neurotic symptoms who failed to respond to conventional psychotropic medication were placed on a regimen of phenytoin. The modal dosage was 50 mg 3-times daily and treatment ranged between 6 to 19 weeks. The results, assessed on a 30-item symptom checklist, indicated that 35 (85%) of the 41 patients improved, 32 (78%) to a statistically significant degree. Few side-effects were reported and occurred in only 6patients on a higher dosage of 200 mg per day. It is suggested that phenytoin is a drug with therapeutic potential in long-standing neurotic conditions.