The effect of pinaverium bromide (LA 1717) on the lower oesophageal sphincter

Summary

An acute, double-blind study was carried out in 8 healthy male volunteers to investigate any effect of a new antispasmodic, pinaverium bromide, compared with placebo on the lower oesophageal sphincter. Manometric measurements showed no significant differences in resting pressures either after placebo or a therapeutic dose (200 mg) of pinaverium bromide, suggesting that the active drug does not cause any impairment of function of the lower oesophageal sphincter.

Key Words::

• Pinaverium bromide
• Antispasmodics
• oesophago-gastric junction