Abstract
The National Institute of Dental Research [NIDR] (subsequently redesignated the National Institute of Dental and Craniofacial Research [NIDCR] of the National Institutes of Health [NIH]) has created a historical report on the development of pain research at the NIH over the past half century. This report documents that history and explains how much of what is now known about the pathophysiology and management of pain evolved from work of that Institute. Beginning with an exploration of dental pain, the work resulted in creation of animal models and clinical research that has proved understanding of mechanisms and treatments. The pioneering work of Dr. Ronald Dubner and many of his colleagues at the NIDR, the development of the Neurobiology and Anesthesiology Branch, the interdisciplinary approach developed within the Institute, the drug testing program and the ongoing work of the Institute are described.
KEYWORDS:
- National Institutes of Health
- NIH
- National Institute of Dental Research
- NIDR
- National Institute of Dental and Craniofacial Research
- NIDCR
- neurobiology
- anesthesiology
- dynorphin
- Dubner
- Max
- Bennett
- Driscoll
- Krsheover
- Sessle
- Govbel
- Gruelich
- Ganz
- Beitel
- Bushnell
- Gary Duncan
- Hayes
- Kenshalo
- Maixner
- Oliveras
- Brown
- Gracely
- McGrath
- Kwilocz
- Dionne
- Xie
- Lynch
- Ruda
- Costa
- Iodarola
- Ren
- DeLeon
- Nahin
- Gu
- Messersmith
- Coghill