Fibromyalgia Syndrome:

Abstract

Objectives: To review the clinical features and the spectrum of associated conditions in fibromyalgia syndrome [FMS]. Results: FMS is characterized by widespread pain, multiple tender points, fatigue, poor sleep, swollen feeling, and paresthesia. Data in recent years suggest that FMS is part of a spectrum of syndromes which I have termed "dysfunctional spectrum syndrome" [DSS]. The members of the DSS family include irritable bowel syndrome, chronic fatigue syndrome, regional fibromyalgia, temporomandibular dysfunction syndrome, tension-type headaches, migraine, and primary dysmenorrhea, among others. The most important pathophysiological mechanisms involved in DSS seem to be an aberration of neurohormonal functions. Conclusions: FMS is a characteristic syndrome that belongs to the DSS family. DSS is one of the most common forms of illness that afflicts human beings, causing much distress and suffering. It deserves serious research focus.

KEYWORDS:

• Fibromyalgia
• dysfunctional spectrum syndrome
• diagnosis
• affective spectrum disorders
• depression