Muscle Studies in Fibromyalgia Syndrome

Abstract

A prominent theory to explain skeletal muscle pain in fibromyalgia [FMS] holds that there is inadequate high-energy phosphate for functional demands. That "energy crisis" hypothesis was not supported when ³¹P-NMR spectroscopy was conducted on resting and exercising FMS muscle compared with muscles of similarly deconditioned controls. These findings suggest that the "muscle pain" of FMS may be due to central mechanisms.

KEYWORDS:

• Fibromyalgia
• skeletal muscles
• phosphocreatine
• deconditioning
• NMR spectroscopy