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Expert Opinion on Therapeutic Patents Volume 10, 2000 - Issue 9
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Miscellaneous

Amide derivatives as cytokine inhibitors

Pages 1451-1454 | Published online: 25 Feb 2005
 
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Abstract

The two indicated patents describe benzamide derivatives that are designed to inhibit p38 MAP kinase. This enzyme plays a key role in the biosynthesis of the pro-inflammatory cytokines TNF-α and IL-1. These patents report in vitro and ex vivo data for a small number of the compounds described therein.

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