Polymyxin-metal complexes and their biological use

Abstract

Polymyxins are cyclic peptide antibiotics isolated from Bacillus colistinus. These generally readily form salts with acids. Polymyxin A, B, C, D and E have also been isolated, but only polymyxin B and polymyxin E (colistin) are used clinically. They have bactericidal activity against Gram-negative bacteria, especially, Psudomonas.

• antibacterial
• autoimmune disease
• Gram-negative bacterium infection
• radiodiagnostics