Inhibition of protein–protein interaction

Abstract

Tracts of repeated glutamine regions can cause aggregation of the proteins that contain them, causing misfolding, loss of function and ultimately a disease state, both from the loss of function and from the plaques and tangle that result from the protein precipitates. The authors propose the use of oligopeptides to prevent the formation of such aggregates.

• folding diseases
• polyglutamine (poly Q)
• protein aggregation
• protein misfolding