Novel guanidino compounds

Abstract

This application discloses a class of guanidine derivatives as melanocortin-4 receptor (MC4R) agonists. These compounds appear to build on a previous Chiron application relating to substituted guanidinobenzamides. The 25 compounds disclosed in the application rely a guanidine fragment that is built up from 2(S)-methylpiperazine and (+)-isopinocampheyl amine. Although no detailed biological data are provided in the application, an analysis of the 25 compounds suggests some moieties may give rise to more preferred compounds as MC4R agonists than others.

• Chiron
• guanidine
• melanocortin-4 receptor (MC4R)
• melanocortins
• obesity