Anticancer activity of artemisinin-derived trioxanes

Gary H Posner Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA; Malaria Research Institute, John Hopkins University, Baltimore, MD 21205, USA

John D’Angelo Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA; Malaria Research Institute, John Hopkins University, Baltimore, MD 21205, USA

Paul M O’Neill Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, UK; Department of Pharmacology and Therapeutics, Sherrington Buildings, University of Liverpool, Liverpool L69 3GE, UK

Amy Mercer Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, UK; Department of Pharmacology and Therapeutics, Sherrington Buildings, University of Liverpool, Liverpool L69 3GE, UK

Abstract

The recent scientific and patent literature on therapeutically promising anticancer trioxanes derived from the antimalarial artemisinin are reviewed through mid-2006. Several of these new chemical entities, especially some trioxane dimers, have selective and very potent anticancer activity even at low nanomolar concentrations. A major opportunity exists for the development of these and related trioxanes into anticancer drug candidates.

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Acknowledgment

The NIH (AI-34885) is thanked for financial support of the peroxide chemotherapy research programme at John Hopkins University.

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Anticancer activity of artemisinin-derived trioxanes

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Anticancer activity of artemisinin-derived trioxanes

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