Carbonic anhydrase IX inhibitors: fluorescent sulfonamides as therapeutic and diagnostic agents

Abstract

This patent application discloses a novel class of strong carbonic anhydrase IX inhibitors bearing fluorescent tails. These compounds are claimed for use as therapeutic and imaging agents of hypoxic tumours, which are poorly responsive to classical chemo- and radiotherapies and constitute a novel strategy for cancer management.

Keywords::

• anticancer agents
• CA IX
• carbonic anhydrase IX
• hypoxic tumour
• sulfonamide