Acetylcholinesterase inhibitors based on carbamic acid quinolin-6-yl esters

Abstract

The application claims two related kinds of carbamic acid esters, namely the ones of quinolin-6-ol and 1-substituted 1,2,3,4-tetrahydroquinolin-6-ols as novel inhibitors of acetylcholinesterase. Hexyl-, heptyl- and substituted phenyl-carbamic acids were prepared, in which the 1-position of the tetrahydro-quinolinol was either unsubstituted or bore a methyl or benzyl group. Some data concerning their in vitro inhibition are presented, as is the testing of a set of compounds in an in vivo assay (amelioration of scopolamine-induced cognitive impairment in a passive avoidance test), in which the compounds tested showed cognitive improvements comparable to standard Alzheimer's disease drugs. These compounds are among the few patents with novel templates for acetylcholinesterase-inhibiting carbamates described in the past 3 years.

Keywords::

• acetylcholinesterase (AChE) inhibitor
• carbamic acid esters
• dementia
• peripheral effects of AChE
• quinolin-6-ols
• 1,2,3,4-tetrahydroquinolin-6-ols