Carbonic anhydrase inhibitors: an editorial

Abstract

This issue of Expert Opinion on Therapeutic Patents is dedicated to carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs), a highly dynamic research topic in the last years. Several review articles and patent analyses on diuretics and antiglaucoma, antiepileptic, anti-obesity and anticancer agents belonging to the pharmacological class of the CAIs are presented, together with a review on bacterial, fungal and protozoan CAs and their inhibition as a novel means of designing anti-infectives.

Keywords::

• anticancer
• antiglaucoma
• anti-obesity
• carbonic anhydrase
• coumarin
• dithiocarbamate
• diuretic
• inhibitor
• polyamine
• sulfonamide

Acknowledgments

Research from the author's laboratory was financed in part by several grants of the 6th and 7th Framework Programme of the European Union (DeZnIT, Metoxia, Gums and Joints, and Dynano projects).