Carbamylated erythropoietin to treat neuronal injury: new development strategies

Abstract

Background: Carbamylated erythropoietin (CEPO) is a modified erythropoietin molecule not affecting hematocrit. It is a potentially important pharmacological agent that may be applied to the treatment of several diseases affecting central and peripheral system neurons. Objective: Carbamylated erythropoietin is a prime candidate for development because of its potent cell survival and function enhancing effects. This article reviews the preclinical development profile of CEPO in animal models to determine whether further clinical development is justified. Methods: The review spans a detailed analysis of patents and scientific publications related to CEPO in animal models. Results/conclusions: Use of CEPO in treating diseases such as stroke and traumatic brain and spinal cord injuries is important because these conditions affect millions of patients every year. Extensive preclinical studies support further clinical studies of CEPO for acute ischemic stroke. However, further studies are required for testing CEPO in patients with many other indications.

Keywords::

• clinical trial
• diabetes
• erythropoietin
• hematopoietic
• neuroprotection
• recovery
• spinal cord injury
• stroke
• traumatic brain injury