Abstract
The literature on tachykinin antagonists published during the second semester of 1994 is reviewed with emphasis on the potential clinical indications for antagonists of the three neurokinin receptor families, namely NK1, NK2 and NK3 . For each therapeutic domain, particular attention is given to the development of adequate experimental animal models needed to evaluate new compounds in vitro and in vivo. Finally, recent developments in the molecular biology of NK1 receptors and design of new non-peptide NK1 antagonists are presented.