The use of desmoteplase (bat saliva) in the treatment of ischaemia

Abstract

Introduction: In an era of ageing global populations and accumulation of cardiovascular risk factors, the importance of reperfusion/recanalisation therapies in treating vascular occlusive disease is growing. There are multiple thrombolytic agents available, including bat saliva-derived plasminogen activator.

Areas covered: A peer reviewed literature search was conducted and focus was on the data on the use of desmoteplase in the treatment of ischaemic stroke.

Expert opinion: Currently, there is not enough evidence for clinical use in ischaemic stroke and further Phase III studies are underway. At this stage, desmoteplase remains an investigational compound.

Keywords::

• desmoteplase
• ischaemia
• stroke
• thrombolysis