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Expert Opinion on Biological Therapy Volume 14, 2014 - Issue 7
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Original Research

Host tissue integration process in abdominal wall defect repair: a comparison of two porcine-derived grafts in a long-term study

Zhengni LiuShanghai JiaoTong University, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Hernia and Abdominal Wall Surgery Center, Department of General Surgery, Shanghai 200011, PR China+86 21 23271699 5168; +86 21 63087768; [email protected]
, MA,
Zhi YangShanghai JiaoTong University, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Hernia and Abdominal Wall Surgery Center, Department of General Surgery, Shanghai 200011, PR China+86 21 23271699 5168; +86 21 63087768; [email protected]
, MA,
Zhiyuan ZhouShanghai JiaoTong University, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Hernia and Abdominal Wall Surgery Center, Department of General Surgery, Shanghai 200011, PR China+86 21 23271699 5168; +86 21 63087768; [email protected]
, MA,
Zhicheng SongShanghai JiaoTong University, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Hernia and Abdominal Wall Surgery Center, Department of General Surgery, Shanghai 200011, PR China+86 21 23271699 5168; +86 21 63087768; [email protected]
, MA,
Huichun WangShanghai JiaoTong University, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Hernia and Abdominal Wall Surgery Center, Department of General Surgery, Shanghai 200011, PR China+86 21 23271699 5168; +86 21 63087768; [email protected]
, MA,
JianJun YangShanghai JiaoTong University, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Hernia and Abdominal Wall Surgery Center, Department of General Surgery, Shanghai 200011, PR China+86 21 23271699 5168; +86 21 63087768; [email protected]
, MD,
Rui TangShanghai JiaoTong University, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Hernia and Abdominal Wall Surgery Center, Department of General Surgery, Shanghai 200011, PR China+86 21 23271699 5168; +86 21 63087768; [email protected]
, MD PhD,
Qiang TanShanghai Jiao Tong University, Shanghai Chest Hospital, Shanghai Lung Cancer Center, Departments of Pathology, Thoracic Surgery, Shanghai, 200030, PR China
, MD &
Yan GuShanghai JiaoTong University, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Hernia and Abdominal Wall Surgery Center, Department of General Surgery, Shanghai 200011, PR China+86 21 23271699 5168; +86 21 63087768; [email protected]
, MD PhD show all
Pages 883-892 | Published online: 07 Apr 2014
 
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Abstract

Background: The aim of this study was to compare the host tissue integration process and biomechanical behaviour after implantation of porcine small intestine submucosa (PSIS) and porcine acellular dermal matrix (PADM) grafts in a rat abdominal wall defect model during a long-term follow-up of 360 days.

Objectives: Full-thickness abdominal wall defects were created in 40 Sprague–Dawley rats and repaired with either PSIS or PADM grafts. Rats were sacrificed at 14, 30, 90 and 360 days to evaluate the presence of herniation, infection, adhesions and changes in thickness and strength properties of the regenerated tissue at the defect site. Histopathology and immunohistochemistry were performed to evaluate the host tissue integration process assessed by the level of collagen deposition, vascularization and inflammatory host sub-chronic and chronic responses.

Results: PADM grafts had greater strength in vitro (p < 0.01). Moreover, the strength of the PADM grafts integrated with the surrounding host tissues was greater than that of the PSIS grafts at 360 days postimplantation (p < 0.05). A stronger integration into the host tissue was observed for the PADM grafts, which showed oriented bands of collagen deposition intermixed with similar newly formed blood vessels compared to that of PSIS grafts after 360 days. The PADM grafts showed slower infiltration of macrophages but developed into a more heavily infiltrated tissue compared to the PSIS grafts (p < 0.05). The level of leukocyte infiltration after implantation was similar in both grafts (p > 0.05).

Conclusion: PADM grafts exhibit more delayed but also more effective host integration than PSIS grafts during the 360 days following implantation, supporting the development of more robust abdominal wall strength.

Acknowledgement

Z Liu and Z Yang contributed equally to this work.

Notes

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