Probody therapeutics for targeting antibodies to diseased tissue

Abstract

Probodies are proteolytically activated antibodies engineered to remain inert until activated locally in diseased tissue. In principle, any therapeutic antibody can be converted into Probody™ form. In this perspective, we highlight the emerging therapeutic potential of the Probody approach in the form of conventional IgG-based Probodies as well as in the form of ‘empowered Probody’ formats such as Probody–drug conjugates.

Keywords::

• antibody–drug conjugate
• antibody
• bispecific antibody
• chimeric antigen receptor – T cells
• EGFR
• Jagged
• probody
• protease