Natural IgM-mediated innate autoimmunity: a new target for early intervention of ischemia–reperfusion injury

Abstract

Recent studies showed that innate autoimmunity is an early mechanism for ischemia–reperfusion (I/R) injury. Results from different animal models showed that reperfusion of ischemic tissues elicits an acute inflammatory response involving a complement system, which is activated by autoreactive natural IgM. Moreover, ischemia-specific self-targets were identified. In contrast to the unsuccessful attempts in the past to treat I/R injury, targeting natural IgM-mediated innate autoimmunity may open a new avenue for early intervention.

Keywords::

• innate autoimmunity
• ischemia–reperfusion injury
• natural IgM

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