Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis

Abstract

The development of specific targeted therapies, such as anti-TNF-α treatment, for chronic inflammatory disorders such as rheumatoid arthritis, has significantly improved treatment, although not all patients respond. Targeting cellular adhesion molecules and chemokines/chemokine receptors as regulators of the extravasation and migration of leukocytes may provide a novel approach for the treatment of these diseases. Moreover, the possibility of developing small-molecule antagonists offers an excellent method for the oral delivery of compounds with a short half-life.

Keywords::

• biologicals
• cellular adhesion molecules
• chemokines
• chemokine receptors
• inflammation
• rheumatoid arthritis
• therapy