Cysteinyl leukotriene receptor CysLT₁ as a novel therapeutic target for allergic rhinitis treatment

Abstract

Background: Cysteinyl leukotrienes (cys-LTs) play an important role in allergic rhinitis because CysLT₁ receptor antagonists relieve the symptoms of allergic rhinitis. Objective: I overview the clinical pharmacology of CysLT₁ receptor antagonists and their potential role in patients with allergic rhinitis. Methods: I review the evidence regarding the release of cys-LTs and localization of CysLT₁ receptor on nasal mucosa, and evaluate the clinical efficacy of CysLT₁ receptor antagonist in allergic rhinitis. Results/conclusion: Immunohistochemical studies show that in allergic rhinitis, the major target of CysLT₁ receptor antagonists are the vascular bed and infiltrated leukocytes such as mast cells, eosinophils and macrophages. CysLT₁ receptor antagonists provide a new opportunity for simultaneous management of allergic diseases of the upper and lower respiratory tract.

Keywords::

• allergic rhinitis
• CysLT₁ receptor
• cysteinyl leukotriene

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