Controlled release using mesoporous materials containing gate-like scaffoldings

Abstract

The use of gated mesoporous silica solids as suitable systems for controlled-release protocols is reviewed. These materials are based on mesoporous silica supports that can be prepared with tailor-made pores of around 2 – 10 nm and that show a very large specific surface area (up to 1200 m²/g), thus having a large load capacity. The solids can be additionally functionalised in the external surface with gate-like systems that can be opened on command to allow cargo release. Light, redox reactions, pH, temperature, polarity and enzyme-driven protocols are shown. The possible application in drug delivery protocols is discussed.

Keywords::

• controlled delivery
• gate-like scaffoldings
• hybrid materials
• mesoporous silica