Current advances in sustained-release systems for parenteral drug delivery

Abstract

Major progresses in the development of parenteral sustained-release systems have been made in recent years as evidenced by the regulatory approval and market launch of several new products. Both the availability of novel carrier materials and the advances in method of fabrication have contributed to these commercial successes. With the formulation challenges associated with biologics, new delivery systems have also been evolved specifically to address the unmet needs in the parenteral sustained release of proteins. In this review paper, different new carriers systems and preparation methods are discussed with special focus on their applications to biologicals.

Keywords::

• biodegradable polymer
• chemical conjugation
• implant
• in situ gelling system
• lipid microparticle
• liposome
• micro- and nanoparticulate systems