Advances in non-invasive drug delivery for atherosclerotic heart disease

Abstract

Introduction: Apart from statins, anti-platelet agents and invasive procedures, the anti-atherosclerotic medical weaponry for coronary heart disease (CHD) is scarce and only partially protects CHD patients from major adverse cardiac events.

Areas covered: Several novel non-invasive strategies are being developed to widen the therapeutic options. Among them, drug delivery tools were tested in vivo encompassing liposomes, micelles, polymeric, metallic and lipid nanoparticles used as carriers of statins, corticosteroids, a bisphosphonate, a glitazone, anti-cancer agents, a mycotoxin, a calcium channel blocker and a compound of traditional Chinese medicine. All preparations improved parameters related to atherosclerotic lesions induced in rabbits, rats and mice and reduced neointima formation in experiments aiming to prevent post-stenting restenosis. In subjects submitted to percutaneous coronary intervention, nanoparticle formulations of paclitaxel and alendronate showed safety but are still not conclusive regarding in-stent late loss. The experience of our group in atherosclerotic rabbits treated with non-protein lipid nanoparticles associated with anti-cancer drugs such as paclitaxel, etoposide and methotrexate is summarized, and preliminary safety data in CHD patients are anticipated.

Expert opinion: Taken together, these studies show that non-invasive drug-delivery systems may become promising tools to rescue CHD patients from the risks of severe and life-threatening lesions that should be more energetically treated.

Keywords:

• coronary artery disease treatment
• drug targeting
• liposomes
• nanoemulsions
• nanoparticles

Acknowledgements

The authors are grateful to TM Tavoni for her help in reviewing the manuscript.

Declaration of interest

RC Maranhão is recipient of a 1A Research Award from the National Council for Scientific and Technological Development (CNPq, Brasilia, Brazil). Our studies on drug delivery were supported by the Foundation for Research Support of the State of São Paulo (FAPESP São Paulo, Brazil), by the Federal Agency for Support of Studies and Projects (FINEP, Rio de Janeiro, Brazil) and by CNPq. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript other than those disclosed.

Notes

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