Drug delivery strategies for poorly water-soluble drugs

Abstract

The drug candidates coming from combinatorial chemistry research and/or the drugs selected from biologically based high-throughput screening are quite often very lipophilic, as these drug candidates exert their pharmacological action at or in biological membranes or membrane-associated proteins. This challenges drug delivery institutions in industry or academia to develop carrier systems for the optimal oral and parenteral administration of these drugs. To mention only a few of the challenges for this class of drugs: their oral bioavailability is poor and highly variable, and carrier development for parenteral administration is faced with problems, including the massive use of surface-active excipients for solubilisation. Formulation specialists are confronted with an even higher level of difficulties when these drugs have to be delivered site specifically. This article addresses the emerging formulation designs for delivering of poorly water-soluble drugs.

Keywords::

• cyclodextrin
• emulsion
• insoluble
• liposomes
• nanosuspension
• solid dispersion
• solid lipid nanoparticles

Acknowledgment

A Fahr thanks FW Richter (Divisional Vice President, Abbott Laboratories) for stimulating discussions.

Notes