Aiming for the heart: targeted delivery of drugs to diseased cardiac tissue

Abstract

Background: The development of a number of regenerative strategies in recent years for curing heart disease represents a paradigm shift away from conventional approaches which aim to manage heart disease. Effective administration of pharmaceutical agents targeted directly to the diseased tissue is the key to unlocking the potential of regenerative strategies, which could augment current conventional treatments. Objective: The authors review recent advances in targeted drug delivery to diseased cardiac tissue. Methods: Various therapeutic methodologies designed to selectively deliver pharmaceutical agents to diseased cardiac tissue are discussed in this review. Conclusion: Targeted delivery of survival and engraftment promoting factors to damaged cardiac tissue can be an important strategy, for example, in creating a suitable microenvironment encouraging the engraftment of stem cells. Further progress in this emerging field is contingent on the discovery of new biomarkers that are upregulated in damaged cardiac tissue and can be targeted for selective drug delivery. Once fully realized, breakthroughs in this field will have direct applications in the diagnosis and treatment of heart disease through more effective tissue-specific drug delivery and improved imaging modalities.

Keywords::

• adhesion molecules
• antibody targeting
• cardiac imaging
• cardiac regeneration
• heart disease
• liposomes
• microbubbles
• microenvironment
• myocardial infarction
• stem cells
• targeted drug delivery

Acknowledgements

We would like to thank Parkson Chong for the use of his laboratory facilities. MF Kiani is an Established Investigator of the American Heart Association. This work was supported by grants from the Susan G Komen Foundation (to MF Kiani), DOD Breast Cancer Research Program (to MF Kiani) and the National Heart, Lung and Blood Institute Faculty Career Development Award (to D Crabbe).

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