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Declaration of interest
The authors were supported by grants from the Instituto de Salud Carlos III co-founded by Fondo Europeo de Desarrollo Regional – FEDER (contract numbers: PI04/1688, P10-CTS-6470, PI12-00620, PI 12-00378, AC-0073-2013) EASL registry research grant 2014, and by the Agencia Española del Medicamento. CIBERehd is funded by Instituto de Salud Carlos III. The funding sources had no involvement in the study design; in the collection, analysis, and interpretation of data; in the writing of the report or in the decision to submit the manuscript for publication. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.