Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development of in vitro high-speed screening systems

Ai Tamura Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan +81 45 924 5800; +81 45 924 5838; [email protected]

Ran An Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan +81 45 924 5800; +81 45 924 5838; [email protected]

Yuichiro Hagiya Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan +81 45 924 5800; +81 45 924 5838; [email protected]

Kazuyuki Hoshijima Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan +81 45 924 5800; +81 45 924 5838; [email protected]

, PhD,

Takashi Yoshida Yokogawa Electric Corporation, Life Science Business Headquarters, Drug Discovery Solution Department, Kanazawa, Japan

, PhD,

Kenta Mikuriya Yokogawa Electric Corporation, Life Science Business Headquarters, Drug Discovery Solution Department, Kanazawa, Japan

, PhD &

Toshihisa Ishikawa Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan +81 45 924 5800; +81 45 924 5838; [email protected]

, PhD show all

Abstract

Background: Photosensitivity depends on both genetic and environmental factors. Pheophorbide a, present in various plant-derived foods and food supplements, can be absorbed by the small intestine. Accumulation of pheophorbide a and porphyrins in the systemic blood circulation can result in phototoxic lesions on light-exposed skin. Objective: As the human ATP-binding cassette (ABC) transporter ABCG2 has been suggested to be critically involved in porphyrin-mediated photosensitivity, we aimed to develop in vitro screening systems for drug-induced phototoxicity. Conclusion: Functional impairment owing to inhibition of ABCG2 by drugs or its genetic polymorphisms can lead to the disruption of porphyrin homeostasis. This review article provides an overview on drug-induced photosensitivity, as well as our hypothesis on a potential role of ABCG2 in phototoxicity.

Keywords::

Notes

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development of in vitro high-speed screening systems

Information for

Open access

Opportunities

Help and information

Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development of in vitro high-speed screening systems

Abstract

Notes

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature