The role of necroptosis, an alternative form of cell death, in cancer therapy

Xinfang Yu Cancer Research Institute, Xiangya School of Medicine, Central South University, 110 Xiang Ya Road, Changsha 410078, Hunan, China; Cancer Research Institute, Xiangya School of Medicine, Central South University, 110 Xiang Ya Road, Changsha 410078, Hunan, China

Qipan Deng Cancer Research Institute, Xiangya School of Medicine, Central South University, 110 Xiang Ya Road, Changsha 410078, Hunan, China; The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA

Ann M Bode The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA; The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA

Zigang Dong The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA; The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA

Ya Cao Cancer Research Institute, Xiangya School of Medicine, Central South University, 110 Xiang Ya Road, Changsha 410078, Hunan, China. [email protected]; Molecular Imaging Center, Central South University, 110 Xiang Ya Road, Changsha 410078, Hunan, China; Cancer Research Institute, Xiangya School of Medicine, Central South University, 110 Xiang Ya Road, Changsha 410078, Hunan, China. [email protected]; Molecular Imaging Center, Central South University, 110 Xiang Ya Road, Changsha 410078, Hunan, China

Abstract

Programmed cell death plays an important role in animal development, tissue homeostasis and eliminating harmful or virally infected cells. Necroptosis, a novel form of programmed cell death, is caspase independent but RIPK and RIPK3 dependent. Moreover, it is suggested that necroptosis can be specifically inhibited by small molecular inhibitors such as necrostatin-1. Its signaling pathways have something in common with apoptosis, although the molecular mechanisms of necroptosis need to be further elucidated. Previous evidences suggest that necroptosis has significant effects in regulating various physiological processes and disease, such as ischemic brain injury, immune system disorders and cancer. In this review, the molecular mechanism of necroptosis is described and how it could be manipulated in the treatment of cancer is summarized.

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Acknowledgements

The authors thank Jing Yu (Hunan Research Institute of Food Quality Supervision and Inspection, Hunan, China) for her helpful discussions and kind advice.

Financial & competing interests disclosure

This project was supported by the National Basic Research Program of China (2009CB522300), the National Nature Science Foundation of China (90813028 and 30830113) and the Hunan Provincial Innovation Foundation for Postgraduate. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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The role of necroptosis, an alternative form of cell death, in cancer therapy

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The role of necroptosis, an alternative form of cell death, in cancer therapy

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