Bladder carcinoma: understanding advanced and metastatic disease with potential molecular therapeutic targets

Hashim Uddin Ahmed Institute of Urology, University College London Hospitals, Euston Road, London, UK. [email protected]

Manit Arya Institute of Urology, University College London Hospitals, Euston Road, London, UK. [email protected]

Hitendra RH Patel Institute of Urology, University College London Hospitals, Euston Road, London, UK. [email protected]

Abstract

This article is an expert review of bladder cancer genetics focusing on genetic changes and their significance in the pathogenesis and progression of bladder transitional cell carcinoma, in particular, muscle-invasive disease. Alongside the relevant genetic markers and their products, new therapeutic targets and agents that are being developed are presented.

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Bladder carcinoma: understanding advanced and metastatic disease with potential molecular therapeutic targets

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Bladder carcinoma: understanding advanced and metastatic disease with potential molecular therapeutic targets

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