Mood disorders medications: predictors of nonadherence – review of the current literature

Maurizio Pompili Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy. [email protected]; Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy. [email protected]

Paola Venturini Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy; Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy

Mario Palermo Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy; Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy

Henry Stefani Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy; Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy

Maria Elena Seretti Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy; Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy

Dorian A Lamis Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA

Gianluca Serafini Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy; Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy

Mario Amore Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genova, Genova, Italy; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genova, Genova, Italy

Paolo Girardi Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy; Department of Neuroscience, Mental Health and Sensory Organs – Suicide Prevention Center, Sant’ Andrea Hospital, Sapienza University of Rome, Italy

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Abstract

Studies have shown that there are several factors that predict nonadherence among patients with mood disorders. The aim of the present review is to identify the predictors of nonadherence among these patients. A careful review of the literature was conducted investigating several potential predictors of nonadherence among patients with mood disorders. A total of 217 relevant articles from peer-reviewed journals were considered, and articles that met our inclusion criteria (n = 54) were selected for this review. The authors identified several predictors of nonadherence among patients with mood disorders including younger age (below 40 years old), comorbidity with substance use and personality disorders, patients’ beliefs, poor insight, illness severity, treatment-related side effects, specific features of the disease and a poor therapeutic alliance. Substance use disorder and illness severity are significant predictors of nonadherence especially in patients with bipolar disorder; whereas, treatment side effects are of primary importance for depressive disorder. The authors could not carry out a meta-analysis given that the studies considered in this review assessed patients at different time points and included different measurements of nonadherence. Moreover, articles cited in this review may reflect the authors’ choice, and the authors did not investigate the adherence to a specific class of drugs commonly used in the management of mood disorders. Given the high social, clinical and economic impact of nonadherence among patients who are affected by mood disorders, it is critical to recognize patients at high risk of nonadherence in order to inform future strategies to examine and improve adherence to treatment. Further research is needed to clarify this issue.

Keywords::

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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Mood disorders medications: predictors of nonadherence – review of the current literature

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Mood disorders medications: predictors of nonadherence – review of the current literature

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