What is the best adjuvant treatment for very young patients with medulloblastoma?

James W Clarke Resident, Ohio State University Medical Center, Department of Radiation Medicine, Arthur G James Cancer Hospital, 300 West 10 Avenue, Ste 083A, Columbus, OH 43210, USA. [email protected]

Mersiha Hadziahmetovic Ohio State University Medical Center, Department of Radiation Medicine, Arthur G James Cancer Hospital, 300 West 10 Avenue, Ste 083A, Columbus, OH 43210, USA. [email protected]

Katherine Tzou Ohio State University Medical Center, Department of Radiation Medicine, Arthur G James Cancer Hospital, 300 West 10 Avenue, Ste 083A, Columbus, OH 43210, USA. [email protected]

Ching C Lau Associate Professor of Pediatrics; Head of Cancer Genomics Program; Director of Genomic Profiling Core Lab, Baylor College of Medicine, Texas Children’s Cancer Center, 6621 Fannin Street, MC 3-3320, Houston, TX 77030-2399, USA. [email protected]

Arnold C Paulino Associate Professor of Radiation Oncology & Pediatrics, Arnold Baylor College of Medicine, The Methodist Hospital, Department of Radiation Oncology, 6565 Fannin Sreet, DB1-077, Houston, TX 77030, USA. [email protected]

John C Grecula Associate Professor of Radiation Medicine, Ohio State University Medical Center, Department of Radiation Medicine, Arthur G James Cancer Hospital, 300 West 10 Avenue, Ste 070B, Columbus, OH 43210, USA . [email protected]

Joseph F Montebello Associate Professor of Radiation Medicine, Ohio State University Medical Center, Department of Radiation Medicine, Arthur G James Cancer Hospital, 300 West 10 Avenue, Ste 072B, Columbus, OH 43210, USA. [email protected]

Nina A Mayr Professor and Chairperson, Ohio State University Medical Center, Department of Radiation Medicine, Arthur G James Cancer Hospital, 300 West 10 Avenue, Ste 080B, Columbus, OH 43210, USA. [email protected]

Simon S Lo Associate Professor of Radiation Medicine & Neurosurgery; Director of Neuro-Radiation Oncology and Stereotactic Radiosurgery; Residency Program Director, Ohio State University Medical Center, Department of Radiation Medicine, Arthur G James Cancer Hospital, 300 West 10 Avenue, Ste 088A, Columbus, OH 43210, USA. [email protected]

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Abstract

The standard treatment for medulloblastoma is surgery followed by adjuvant chemotherapy and external beam radiotherapy to the craniospinal axis and posterior fossa. However, in very young children, craniospinal irradiation has a more significant detrimental effect in terms of neurocognitive function and growth. This article reviews the different strategies used for very young patients with medulloblastoma.

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What is the best adjuvant treatment for very young patients with medulloblastoma?

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What is the best adjuvant treatment for very young patients with medulloblastoma?

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