2,248
Views
4
CrossRef citations to date
0
Altmetric
Editorial

CD11b+ DCs rediscovered: implications for vaccination

&
Pages 445-447 | Published online: 25 Feb 2014
 

Abstract

Dendritic cells (DCs) are potent antigen sensing and presenting cells, able to both initiate and orchestrate complex immune responses. DCs are optimally equipped to recognize pathogens, as well as self-antigens and vaccine components, and instruct the type, magnitude and specificity of the ensuing immunity. However, the DC population is remarkably heterogeneous and consists of multiple subsets with different ontogeny, differentiation and functional specializations. Therefore, a deeper understanding of DC subset biology is fundamental for the development and implementation of innovative vaccination strategies.

Financial & competing interests disclosure

This work was supported by the Singapore Immunology Network core grant. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.