Value of classical criteria for diagnosis of cardiac amyloidosis re-evaluated with magnetic resonance

Abstract

The noninvasive diagnosis of cardiac amyloidosis (CA) is often challenging. ECG abnormalities are common but lack both sensitivity and specificity. While some features on transthoracic echocardiography have confirmed the classical picture of CA, they have generally been validated against endomyocardial biopsy and thus are indicative of advanced disease. The ability of cardiac magnetic resonance to characterize the myocardium has opened a new door in the noninvasive diagnosis of CA, representing an opportunity to revisit the role of traditional ECG and transthoracic echocardiography diagnostic crtieria in earlier disease stages.

Keywords::

• cardiac amyloidosis
• cardiac magnetic resonance
• diagnosis
• echocardiography
• electrocardiography

Financial & competing interest disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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