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Abstract
With the advent of biologics, the survival and quality of life of patients diagnosed with metastatic colorectal cancer (mCRC) has improved. These agents include anti-VEGF agents (bevacizumab/aflibercept), anti-EGFR antibodies (panitumumab/cetuximab) and regorafenib (an oral multi-kinase inhibitor). With the use of the novel therapeutics, there was a notable increase in the median survival of patients with mCRC; however, there are still several unmet needs with the use of novel therapeutics in mCRC. The focus of this editorial is to highlight some of these issues alongside results of some of the important clinical trials and other studies presented at the American Society of Clinical Oncology meeting last year.
Financial & competing interests disclosure
JM Hubbard has received research support from Genentech, Boston Biomedical Inc. and PRISM Pharma Co. A Grothey has received research support from Genentech, Bayer, Eisai, Pfizer and Eli-Lilly. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
