Financial & competing interests disclosure
This study was financially supported by BolognAIL, AIRC (IG4987; 5xMille 10007; IG10519), RFO (SA Pileri and PP Piccaluga), Fondazione Cassa di Risparmio in Bologna, Fondazione della Banca del Monte e Ravenna and Progetto Strategico di Ateneo 2006 (SA Pileri and PP Piccaluga). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.