Factor XI and traveling waves: the key to understanding coagulation in hemophilia?

Fazoil I Ataullakhanov Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 4 Kosygina St., Moscow, Russia and HemaCore LLC, 3, 4th 8 Marta St., Moscow, Russia and National Research Center for Hematology, Ministry of Healthcare and Social Development, 4a Novyi Zykovskyi Pr., Moscow, Russia. [email protected]

Natalia M Dashkevich Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 4 Kosygina St., Moscow, Russia and HemaCore LLC, 3, 4th 8 Marta St., Moscow, Russia and EA 4174 Unité de Recherche sur l’Hémophilie, Universite Lyon 1, Lyon, France

Claude Negrier EA 4174 Unite de Recherche sur l’Hemophilie, Universite Lyon 1, Lyon, France and Unité d’Hémostase Clinique, Hôpital Edouard Herriot, Lyon, France

Mikhail A Panteleev Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 4 Kosygina St., Moscow, Russia and HemaCore LLC, 3, 4th 8 Marta St., Moscow, Russia and National Research Center for Hematology, Ministry of Healthcare and Social Development, 4a Novyi Zykovskyi Pr, Moscow, Russia

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Financial & competing interests disclosure

The authors are financially supported by ‘Bourse de Thèse en Cotutelle’ from the French Embassy in Russia (NM Dashkevich), the Russian Foundation for Basic Research Grants 12-04-00438 (FI Ataullakhanov), 11-04-00303 and 12-04-33055 (MA Panteleev) and the Russian Academy of Sciences Presidium Basic Research Programs ‘Molecular and Cellular Biology’ (MA Panteleev), ‘Basic Science for Medicine’, ‘Integrative Physiology’ and ‘Molecular Mechanisms of Physiologic Functions’ (FI Ataullakhanov). NM Dashkevich, MA Panteleev and FI Ataullakhanov are affiliated with HemaCore LLC, which holds several patents and patent applications on the diagnostic use of coagulation assays in spatially distributed systems currently developed under the trade name of Thrombodynamics. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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Factor XI and traveling waves: the key to understanding coagulation in hemophilia?

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Factor XI and traveling waves: the key to understanding coagulation in hemophilia?

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