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Abstract
Open-angle glaucoma and ocular hypertension require chronic topical treatment whose active ingredients can have some local side effects. Furthermore, different preservatives are present in the bottles to avoid contamination by common pathogens. Among all the preservatives, benzalkonium chloride is the most common and its toxic effects on the ocular tissue are well known. The purpose of this article is to investigate the ocular effects of glaucoma medication on ocular tissue, and in particular the ocular changes caused by preserved antiglaucoma drugs. Moreover, the shift from preservative-containing to preservative-free drugs, or the use of alternative preservatives with a lighter toxicity could be useful to decrease the negative impact of glaucoma medications on ocular tissues and to improve the patient’s compliance. The outcome of filtering surgery could change on the basis of a previous topical therapy.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.