![Sample our Engineering & Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5933/TOC-Subject-Sample-2021-Engineering-Tech.jpg"})
Abstract
In vitro and in vivo results reflect that functionalized carbon nanotubes (f-CNTs) are promising for the development of unique delivery systems of anticancer drugs. Functionalization of CNTs and drug loading are realized by covalent attachment and/or physical approaches. Poly(ethylene glycol) is the most adopted species for functionalization, which can increase the dispersity in aqueous solution and biocompatibility of CNTs. Several types of anticancer drugs, such as paclitaxel and doxorubicin, are loaded onto f-CNTs and their treatment efficacy has been demonstrated in vitro and in vivo. However, f-CNTs of well-controlled structures, such as uniform length and well-defined chemistry, which are not available so far, are important to solve the current controversy over the mechanisms of cell uptake of f-CNTs, and are a prerequisite to investigate whether f-CNTs can be platform materials for anticancer drug delivery with improved efficacy.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.