Temperature-sensitive polymers for drug delivery

Scott D Fitzpatrick School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada; School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada

Lindsay E Fitzpatrick The Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, M5S 3G9, Canada; The Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, M5S 3G9, Canada

Ajit Thakur School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada; School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada

Mohammad A Jafar Mazumder Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada; Department of Chemistry, King Fahd University of Petroleum & Minerals, University Blvd, Dhahran-31261, Saudi Arabia; Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada; Department of Chemistry, King Fahd University of Petroleum & Minerals, University Blvd, Dhahran-31261, Saudi Arabia

Heather Sheardown School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada; Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada; School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada. [email protected]; Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada

Abstract

The ability to undergo rapid changes in response to subtle environmental cues make stimuli- responsive materials attractive candidates for minimally invasive, targeted and personalized drug delivery applications. This special report aims to highlight and provide a brief description of several of the significant natural and synthetic temperature-responsive materials that have clinical relevance for drug delivery applications. This report examines the advantages and disadvantages of natural versus synthetic materials and outlines various scaffold architectures that can be utilized with temperature-sensitive drug delivery materials. The authors provide a commentary on the current state of the field and provide their insight into future expectations for temperature-sensitive drug delivery, emphasizing the importance of the emergence of dual and multiresponsive systems capable of responding precisely to an expanding set of stimuli, thereby allowing the development of disease-specific drug delivery vehicles.

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Financial & competing interests disclosure

The authors would like to acknowledge NSERC and the NSERC 20/20 Ophthalmic Materials Network for funding. H Sheardown is the founder of the 20/20 NSERC Ophthalmic Materials Network, which had/has ties with and receives funding from the following industrial partners: Alimera Sciences, CIBA Vision Corporation, Custom Contact Lenses, GlaxoSmithKline, Fovea Pharmaceuticals, iCo Therapeutics, Siltech Corporation, Take Control Cosmedix, Vista Optics Limited and Walsh Medical Devices Incorporated. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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Temperature-sensitive polymers for drug delivery

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Temperature-sensitive polymers for drug delivery

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