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Abstract
Evaluation of: Tissari P, Zumla A, Tarkka E et al. Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform: an observational study. Lancet 375(9710), 224–230 (2010).
Rapid and accurate detection of life-threatening microbial pathogens with high morbidity and mortality is important for the treatment of suitable antibiotics to patients with infectious diseases. Recently, DNA microarray-based identification of pathogenic microorganisms has attracted much attention from clinical researchers owing to its efficiency, specificity and reproducible high-throughput capacities, compared with conventional culture-based diagnosis, which require a long period of time for cultivation and labor-intensive assay steps. In this article, we review recently published microarray-based diagnostic studies for accurate and rapid identification of pathogens infected in bloodstream and discuss the advantages and limitations over conventional diagnostic methods.
Financial & competing interests disclosure
The work performed in our laboratory was supported by the Korean Systems Biology Research Project (20090065571) of the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea. Further supports by the World Class University Program (R32-2008-000-10142-0) of the MEST, LG Chem Chair Professorship, IBM SUR program, and Microsoft are appreciated. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.