Brain tumor location and psychiatric symptoms: is there any association? A meta-analysis of published case studies

Subramoniam Madhusoodanan St John’s Episcopal Hospital, Department of Psychiatry, 327 Beach 19th Street, Far Rockaway, NY 11691, USA. [email protected]; State University of New York, Health Science Center, NY, USA; St John’s Episcopal Hospital, Department of Psychiatry, 327 Beach 19th Street, Far Rockaway, NY 11691, USA. [email protected]; State University of New York, Health Science Center, NY, USA

Mark GA Opler New York University, NY, USA; The PANSS Institute, NY, USA; New York University, NY, USA; The PANSS Institute, NY, USA

Despina Moise Wangui Hospital, Wangui, New Zealand; Wangui Hospital, Wangui, New Zealand

Jessica Gordon The PANSS Institute, NY, USA; The PANSS Institute, NY, USA

Deepa M Danan Columbia University, NY, USA; Columbia University, NY, USA

Abhishek Sinha St. George’s Hospital, London, UK; St. George’s Hospital, London, UK

Ramesh P Babu NYU Medical Center, NY, USA; NYU Medical Center, NY, USA

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Abstract

A meta-analytic study of reports of brain tumors and psychiatric symptoms for the past 50 years was conducted to examine potential associations between tumor location and psychiatric symptoms. Results demonstrated that there is a statistically significant association between anorexia symptoms and hypothalamic tumors. For the rest of the brain regions a statistically significant association could not be definitively determined. However, several of the regions demonstrated an increased likelihood of associated symptoms when compared with other regions. The methodological limitations of this analysis are discussed.

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Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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Brain tumor location and psychiatric symptoms: is there any association? A meta-analysis of published case studies

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Brain tumor location and psychiatric symptoms: is there any association? A meta-analysis of published case studies

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