Neurotrophins in lung health and disease

YS Prakash Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA;[email protected]

Michael A Thompson Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

Lucas Meuchel Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

Christina M Pabelick Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

Carlos B Mantilla Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

Syed Zaidi Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA

Richard J Martin Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA

show all

Abstract

Neurotrophins (NTs) are a family of growth factors that are well-known in the nervous system. There is increasing recognition that NTs (nerve growth factor, brain-derived neurotrophic factor and NT3) and their receptors (high-affinity TrkA, TrkB and TrkC, and low-affinity p75NTR) are expressed in lung components including the nasal and bronchial epithelium, smooth muscle, nerves and immune cells. NT signaling may be important in normal lung development, developmental lung disease, allergy and inflammation (e.g., rhinitis, asthma), lung fibrosis and even lung cancer. In this review, we describe the current status of our understanding of NT signaling in the lung, with hopes of using aspects of the NT signaling pathway in the diagnosis and therapy of lung diseases.

Keywords::

Financial & competing interests disclosure

YS Prakash is supported by NIH grants HL088029 and HL056470, and the Flight Attendants Medical Research Institute. Richard J Martin is supported by NIH grant HL056470 and Christina M Pabelick is supported by NIH grant HL090595. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Neurotrophins in lung health and disease

Information for

Open access

Opportunities

Help and information

Neurotrophins in lung health and disease

Abstract

Financial & competing interests disclosure

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature