Update on Campylobacter jejuni vaccine development for preventing human campylobacteriosis

Abstract

Campylobacteriosis constitutes a serious medical and socioeconomic problem worldwide. Rapidly increasing antibiotic resistance of bacterial strains compels us to develop alternative therapeutic strategies and to search for efficient immunoprophylactic methods. The vast majority of Campylobacter infections in developed countries occur as sporadic cases, mainly caused by eating undercooked Campylobacter-contaminated poultry. The most efficient strategy of decreasing the number of human Campylobacter infections is by implementing protective vaccinations for humans and/or chickens. Despite more than 10 years of research, an effective anti-Campylobacter vaccine has not been developed. This review highlights our increasing knowledge of Campylobacter interaction with host cells and focuses on recently published data describing the efficacy of anti-Campylobacter vaccine prototypes.

Keywords::

• adjuvant
• animal model
• Campylobacter jejuni
• CWC whole-cell vaccine
• immunological host response
• pathogen interaction with eukaryotic cells
• subunit vaccine

Acknowledgements

We thank Cloe James for assistance in the preparation of this manuscript.

Disclaimer

The references cited are representative but are not intended to be comprehensive. As many papers describing influence of the Campylobacter metabolic processes on chicken colonization have recently been published, we consider some selected examples. We apologize to many researchers whose inspiring work has not been cited in our review paper owing to space restrictions.

Financial & competing interests disclosure

This work was supported by a grant from the Ministry of Science and Higher Education (No. N303 116 31/3970). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.