Prevalence of Oral Helicobacter pylori Infection in an Indigenous Community in Southwest Mexico

Abstract

Purpose

Epidemiological studies have been conducted to improve the health and economic quality of life of indigenous communities in Mexico. These studies have found that infections cause frequent health problems. Helicobacter pylori are responsible for conditions ranging from gastritis to stomach cancer. This study determined the prevalence of H. pylori in families from Siltepec, Chiapas, Mexico.

Patient and Methods

Ninety-nine dental plaque samples from 36 families were studied. Real-time PCR was performed to detect H. pylori using previously reported primers. The Mann–Whitney U-test was used for the statistical analysis. According to the family role of H. pylori-positive individuals, the VacA s1/m1 genotype and CagA gene correlated.

Results

The mother had the highest expression of VacA s1/m1-/cagA- with 19% (8/42), followed by the first child with 14.3% (6/42). The major roles for the vacA s1/m1+/cagA- were the mother and first child with 9.5% (4/42), followed by the remaining children with 4.8% (2/42). The vacA s1/m1-/cagA+ genotype was 7.1% (3/42) for the mother and 4.8% (2/42) for the father. Finally, the vacA s1/m1+/cagA+ genotype only appeared in the mother, son I, and son III with 2.4% (1/42).

Conclusion

The vacA s1/m1/cagA genotypes predominated in the mother, suggesting potential transmission between the mother and child during the first years of life.

Plain language summary

Helicobacter pylori is a bacterium that causes duodenal and gastric ulcers and is a risk factor for gastric cancer. It has been found in the dental plaque of children and adults. This study was conducted to identify if the mother can transmit the infection to her children.

Keywords:

• Helicobacter pylori
• infection
• gastrointestinal diseases
• infection transmission
• nutrition

Data Sharing Statement

The data supporting the study findings are available from the corresponding author, Myriam Angelica De La Garza-Ramos, upon reasonable request.

Acknowledgments

We thank Sergio Lozano-Rodriguez, M.D., MWC^®, for his help in translating and editing the manuscript.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis, and interpretation, or all these areas; took part in drafting, revising, or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

This research received no specific grant from funding agencies in the public, commercial, or not-for-profit sectors.