Acute Necrotizing Pancreatitis Complicated with Paroxysmal Nocturnal Haemoglobinuria: A Case Report

Abstract

This report presents a unique case of acute necrotizing pancreatitis(ANP) concomitant with paroxysmal nocturnal hemoglobinuria(PNH), a combination that has not been documented in existing literature. The impact of PNH on ANP and its treatment remains uncertain due to the lack of consensus. The case described herein involves a patient who exhibited both ANP and PNH, subsequently experiencing splanchnic vein thrombosis (SVT), resulting in substantial intra-abdominal and gastrointestinal hemorrhaging. We attempted to analyze the role of PNH in the formation of SVT in ANP and propose some new insights and hypotheses for the treatment of such patients.

Keywords:

• acute necrotizing pancreatitis
• paroxysmal nocturnal hemoglobinuria
• splanchnic vein thrombosis

Ethics and Consent Statement

The authors declare that the case details in this case report do not require any institutional approval for publication. Written informed consent about the case report and accompanying images was obtained from the patient for publication of this report.

Disclosure

The authors declare that they have no conflicts of interest in this work.

Additional information

Funding

This case report was supported by: 1. China Medical and Health Development Foundation, Young and Middle-aged Doctors Excellent Talent, Pei Ying Program, Clinical study on prevention and treatment of exocrine pancreatic insufficiency associated with severe acute pancreatitis. 2. Tianjin Nankai Hospital integrated Traditional Chinese and Western medicine prevention and treatment key technology and program optimization 2022 key project, A multi-omics study of the microenvironment of abdominal inflammation in acute pancreatitis based on minimally invasive individualized integrated traditional Chinese and Western Medicine surgical treatment system, NKYY-IIT-2022-009-2. 3. Tianjin key areas of traditional Chinese medicine science and technology project, Clinical study of combined treatment of TCM and Western medicine with pancreato-intestinal therapy based on peritoneal microecology in the treatment of acute pancreatitis 2022005. 4. Tianjin Natural Science Foundation key project, Establishment of individualized surgical treatment system for severe acute pancreatitis and intelligent evaluation of multimodal imaging. 5. Tianjin Administration of Traditional Chinese Medicine fund of traditional Chinese and Western medicine integrated research project, Study on the change of peritoneal microecology in acute pancreatitis and the effect of Qingyi Decoction 2021006. 6. Tianjin 131 innovative talent team, innovation team for Diagnosis and treatment of acute abdomen related to biliary and pancreatic diseases 201938.