Angiotensinogen and Risk of Stroke Events in Patients with Type 2 Diabetes Mellitus

Abstract

Background

Activation of the renin-angiotensin system (RAS) in diabetic patients is a vital pathophysiological mechanism of cardiovascular complications.

Aim

We aimed to assess whether serum and urinary angiotensinogen levels could predict the risk of stroke events in patients with type 2 diabetes.

Methods

An analysis of the relationships between serum and urinary angiotensinogen levels at baseline and the risk of stroke events was performed in a study consisting of 467 patients with type 2 diabetes with a follow-up of 5 years. Multivariate Cox regression models were built by controlling for a large range of related risk factors.

Results

Kaplan–Meier analysis showed that patients with low estimated glomerular filtration rate (eGFR) <57 mL/min/1.73 m² had a significantly higher risk of stroke events than those with high eGFRs (≥57 mL/min/1.73 m², P=0.040). Our results suggested that urinary angiotensinogen levels (HR=2.74, 95% CI 1.50–5.88, P=<0.001), but not serum angiotensinogen levels (HR=1.42, 95% CI 0.95–2.65, P=0.071), were independent predictors of the risk of stroke events in patients with type 2 diabetes after adjusting for confounding factors. Similarly, sensitivity analysis also suggested that higher urinary angiotensinogen levels still contributed to an increased risk of stroke events (HR=2.71, 95% CI 1.48–5.82, P<0.001) but not serum angiotensinogen levels (HR=1.37, 95% CI 0.89–2.21, P=0.104). Importantly, we found that significant associations only existed in patients with eGFRs<60 mL/min/1.73 m² (HR=2.78, 95% CI 1.59–6.30, P<0.001) but not in patients with eGFRs≥60 mL/min/1.73 m² (HR=1.39, 95% CI 0.95–3.53, P=0.054).

Conclusion

The study suggested that elevated urinary angiotensinogen levels were correlated with a higher risk of stroke events in patients with type 2 diabetes mellitus.

Keywords:

• angiotensinogen diabetes mellitus
• stroke
• Cox proportional hazard regression

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

There is no funding to report.