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ORIGINAL RESEARCH

Melatonin Receptor 1B Genetic Variants on Susceptibility to Gestational Diabetes Mellitus: A Hospital-Based Case–Control Study in Wuhan, Central China

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Pages 1207-1216 | Published online: 20 Apr 2022
 

Abstract

Purpose

The aim of the study was to find out the associations of Melatonin receptor 1B (MTNR1B) genetic variants with gestational diabetes mellitus (GDM) in Wuhan of central China.

Patients and Methods

A hospital-based case–control study that included 1679 women was carried out to explore the associations of MTNR1B single nucleotide polymorphisms (SNPs) with GDM risk, which were analyzed through logistic regression analysis by adjusting age, pre-pregnancy BMI and family history of diabetes. Multifactor dimensionality reduction was applied to determine gene–gene interactions between SNPs.

Results

MTNR1B SNPs rs10830962, rs10830963, rs1387153, rs7936247 and rs4753426 were significantly associated with GDM risk (P<0.05). The rs10830962/G, rs10830963/G, rs1387153/T, and rs7936247/T were risk variants, whereas rs4753426/T was protective variant for GDM development. Fasting plasma glucose (FPG) and 1h-plasma glucose (PG) were significantly different among genotypes at rs10830962 and rs10830963, whereas 2h-PG levels were not. Gene–gene interactions were not found among the five SNPs on GDM risk.

Conclusion

MTNR1B genetic variants have significant associations but no gene–gene interactions with GDM risk in central Chinese population. Furthermore, MTNR1B SNPs have significant relationships with glycemic traits.

Abbreviations

GDM, gestational diabetes mellitus; T2D, type 2 diabetes; GWAS, genome-wide association study; MTNR1B, melatonin receptor 1B; SNPs, single nucleotide polymorphisms; OGTT, oral glucose tolerance test; IADPSG, International Association of Diabetes and Pregnancy Study Groups; FPG, fasting plasma glucose; PG, plasma glucose; MAF, minor allele frequency; ANOVA, analysis of variance; HWE, Hardy–Weinberg Equilibrium; MDR, multifactor dimensionality reduction; LD, linkage disequilibrium; BMI, body mass index; SD, standard deviation; OR, odds ratio; CI, confidence interval; LSD, least significant difference.

Data Sharing Statement

The datasets of this study are available from the corresponding authors on reasonable request.

Ethics Approval and Informed Consent

The study was approved by the institutional review board of Wuhan University of Science and Technology. Informed consent was obtained from all subjects of the study.

Acknowledgments

The authors thank the study participants, hospital staff, research workers and students who participated in this work.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

The authors declare that they have no known competing financial interests or personal relationships or conflicts of interest that could have appeared to influence the work reported in this paper.

Additional information

Funding

This work was supported by The National Natural Science Fund of China (81703239), Chinese Center for Disease Control and Prevention (2018FYH014) and Health Commission of Hubei Province (WJ2018H0134; WJ2018H0145).