Metabolic Syndrome During Pregnancy: Prevalence and Determinants Among Pregnant Women Followed-Up at the Dschang District Hospital, West Region of Cameroon

Abstract

Purpose

Metabolic syndrome (MS) during pregnancy constitutes a serious threat to the mother and child health that will shortly become a major public health issue, especially in developing countries. However, in Cameroon, epidemiological data on MS during pregnancy are still scarce. The aim of this study was to determine the prevalence and determinants of MS among pregnant women followed-up at the Dschang District Hospital (DDH), in the west region of Cameroon.

Patients and Methods

This study was a hospital based cross-sectional study, carried out among pregnant women followed-up at the antenatal care unit of the DDH, from September 2019 to June 2020. Participants were assessed on sociodemographic, lifestyle parameters, and dietary habits using standardized and structured questionnaires. Anthropometric parameters, blood pressure, and biochemical markers were measured using standard procedures. Metabolic syndrome was diagnosed using the HNLBI/AHA definition, modified for pregnant women by Chatzi et al. A participant was recorded as having MS if presenting at least three of the following criteria: Pre-gestational BMI >30 kg/m2; triglycerides ≥150 mg/dl; HDL cholesterol <50 mg/dl; SBP ≥130/DBP ≥85 mm/Hg; and fasting blood glucose ≥100 mg/dl.

Results

Six hundred and four (604) pregnant women were included in the study. The prevalence of MS was 17.88% (95% CI: 15.03–21.14) and its most frequent individual components were low levels of HDL-cholesterol (66.23% (95% CI: 62.36–69.88)) and hypertriglyceridemia (28% (95% CI: 54.31–62.15)). Grand multiparous shows a higher risk of presenting MS (OR:3.06, 95% CI: 1.24–7.12; p = 0.011) compared to nulliparous. Pregestational BMI appears to be the best predictor of MS during pregnancy even after adjustment on age, parity, lifestyle and dietary habits (OR: 46.46, 95% CI: 15.58–138.49; p ˂ 0.0001).

Conclusion

The prevalence of MS on pregnant women in the Dschang health district is 17.88% (95% CI: 15.03–21.14) and its major determinant is pre-gestational obesity. This work provides quality preliminary data for the design and improvement of prevention strategies.

Keywords:

• metabolic syndrome
• pregnancy
• risk factors
• Dschang health district

Abbreviations

HNLBI/AHA, National Heart, Lung and Blood Institute/American Heart Association; NCEP ATP III, National Cholesterol Education Program, Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults; HDL-C, High-density lipoprotein cholesterol; MS, Metabolic syndrome; TG, Triglyceride.

Data Sharing Statement

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Acknowledgments

Authors kindly acknowledge the laboratory and antenatal consultation staff of the Dschang District Hospital as well as all the pregnant women enrolled in the study.

Disclosure

The authors report no conflicts of interest in this work.